Identification of SK3 channel as a new mediator of breast

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cAMPPKA inhibition of SK3 channel reduced both Ca 2

Jan 24,2014 Identification of SK3 channel as a new mediator of breast#0183;SK3 channel mediates the migration of various cancer cells.When expressed in breast cancer cells,SK3 channel forms a complex with Orai1,a voltage-independent Ca2+ channel.This SK3Orai1 complex associates within lipid rafts where it controls a constitutive Ca2+ entry leading to cancer cell migration and bone metastases development.Since cAMP was found to modulate breastTranscription factor ZFHX3 regulates calcium influx in Nov 05,2019 Identification of SK3 channel as a new mediator of breast#0183;1.Introduction.Zinc finger homeobox 3 (ZFHX3,also named as ATBF1 for AT motif binding factor 1) has been reported to be a candidate tumor suppressor in multiple types of cancers,and its genomic deletion or mRNA downregulation promotes the prostate,breast,head and neck,and gastric cancer progression [,,,].Moreover,ZFHX3 was thought to be a differentiation inducer in multipleThe small conductance calcium-activated potassium channel Zur Identification of SK3 channel as a new mediator of breast#252;ck zum Zitat Potier M,Joulin V,Roger S,Besson P,Jourdan ML,Leguennec JY,et al.Identification of SK3 channel as a new mediator of breast cancer cell migration.Mol Cancer Ther.2006;5(11):294653.doi 10.1158/ 1535-7163.MCT-06-0194.

The small conductance calcium-activated potassium channel

Nov 30,2015 Identification of SK3 channel as a new mediator of breast#0183;Metastasis is the survival-determining factor in urothelial carcinoma (UC) of the urinary bladder.The small conductance calcium-activated potassium channel 3 (SK3) enhances tumor cell invasion in breast cancer and malignant melanoma.Since Edelfosine,a glycerophospholipid with antitumoral properties,effectively inhibits SK3 channel activity,our goal was to evaluate SK3 as aThe interactions of apamin and tetraethylammonium are Feb 15,2013 Identification of SK3 channel as a new mediator of breast#0183;The three tested channels (WT,phenylalanine mutant and alanine mutant) were found to be differentially sensitive to TEA,both in the case of SK2 (p = 0.04,KruskalWallis test,N = 13) (Fig.2B) and SK3 (p = 0.02,KruskalWallis test,N = 15) (Fig.3B).Representative traces from whole-cell recording of expressed SK2 WT,SK3 WT,SK2V366F and SK3V520F channel currents (Fig.2,Fig.3 The impact of down-regulated SK3 expressions on Potier M,Joulin V,Roger S,et al.Identification of SK3 channel as a new mediator of breast cancer cell migration.Mol Cancer Ther.2006; 5:29462953.doi

The impact of down-regulated SK3 expressions on

Potier M,Joulin V,Roger S,et al.Identification of SK3 channel as a new mediator of breast cancer cell migration.Mol Cancer Ther.2006; 5:29462953.doiThe SK3/KCa2.3 potassium channel is a new cellular target Recently,we identified SK3/K Ca 2.3 channels as a new mediator of breast and melanoma cancer cell migration (Potier et al.,2006; Chantome et al.,2009).In the present study,we found that edelfosine reduced the migration of MDA-MB-435s cells by decreasing the activity of SK3/K Ca 2.3 channels and limiting Ca 2+ entry into cells.The SK3/K(Ca)2.3 potassium channel is a new cellular Jan 01,2011 Identification of SK3 channel as a new mediator of breast#0183;Identification of SK3 channel as a new mediator of breast cancer cell migration.Potier M,Joulin V,Roger S,Besson P,Jourdan ML,Leguennec JY,Bougnoux P,Vandier C.Mol Cancer Ther,5(11):2946-2953,01 Nov 2006 Cited by 57 articles PMID 17121942

The SK3/K(Ca)2.3 potassium channel is a new cellular

Jan 01,2011 Identification of SK3 channel as a new mediator of breast#0183;Identification of SK3 channel as a new mediator of breast cancer cell migration.Potier M,Joulin V,Roger S,Besson P,Jourdan ML,Leguennec JY,Bougnoux P,Vandier C.Mol Cancer Ther,5(11):2946-2953,01 Nov 2006 Cited by 57 articles PMID 17121942TRP channels diagnostic markers and therapeutic targets Feb 01,2013 Identification of SK3 channel as a new mediator of breast#0183;TRP channels are also involved in Ca 2+ influx across the plasma membrane,elevating the intracellular Ca 2+ concentration ([Ca 2+] i).Cytoplasmic Ca 2+ is a universal signal that activates a myriad of distinct cellular responses including proliferation,apoptosis,migration,or invasion depending on the type of Ca 2+ signal .The Ca 2+ signaling pathways involved in cancer are summarized in Box 2.Supporting Information Novel blocker of onco SK3 channels shRNA specific to SK3 (SK3-cells) or a non-targeting shRNA (SK3+ cells) as previously validated.15 HEK 293 and HEK293T were from ATCC,maintained in Dulbeccos Modified Eagles Medium,supplemented with 10% (v:v) fetal bovine serum (Lonza,France).Stable expression of rat SK2 channels in HEK293 cells were performed as previously

Store-independent Orai1-mediated Ca2+ entry and cancer

Jun 01,2019 Identification of SK3 channel as a new mediator of breast#0183;In 2006,Potier and coworkers reported for the first time the involvement of SK3 channels in cancer cell migration using the MDA-MB-435s cell line .Plasma membrane hyperpolarization was later identified as a key element for SK3 channel-dependent migration in melanoma cells ().Later on,in 2012,the interaction between SK3 and Orai1 was described as a complex that forms a constitutive Ca 2 Some results are removed in response to a notice of local law requirement.For more information,please see here.SK3/TRPC1/Orai1 complex regulates SOCE-dependent colon Jun 14,2016 Identification of SK3 channel as a new mediator of breast#0183;Potier M,Joulin V,Roger S,Besson P,Jourdan ML,Leguennec JY,Bougnoux P,Vandier C.Identification of SK3 channel as a new mediator of breast cancer cell migration.Molecular cancer therapeutics.2006; 5:29462953.

Previous123456NextOverexpression of the SK3 channel alters vascular

Potier M,Joulin V,Roger S,Besson P,Jourdan ML,Leguennec JY,Bougnoux P,Vandier C.Identification of SK3 channel as a new mediator of breast cancer cell migration.Mol Cancer Ther 5 29462953,2006.Pierre BESSON University of Tours,Tours UFR INSERM The SK3 channel,a potassium channel,was recently shown to control cancer-cell migration,a critical step in metastasis outgrowth.Here,we report that expression of the SK3 channel was markedly Pierre BESSON University of Tours,Tours UFR INSERM The SK3 channel,a potassium channel,was recently shown to control cancer-cell migration,a critical step in metastasis outgrowth.Here,we report that expression of the SK3 channel was markedly

P.Bougnoux Semantic Scholar

Mar 01,2002 Identification of SK3 channel as a new mediator of breast#0183;Identification of SK3 channel as a new mediator of breast cancer cell migration.M.Potier,V.Joulin,+5 authors C.Vandier; The SK3 channel,a potassium channel,was recently shown to control cancer cell migration,a critical step in metastasis outgrowth. Breast cancer becomes lethal when visceral metastases develop.P.Bougnoux Semantic ScholarMar 01,2002 Identification of SK3 channel as a new mediator of breast#0183;Identification of SK3 channel as a new mediator of breast cancer cell migration.M.Potier,V.Joulin,+5 authors C.Vandier; The SK3 channel,a potassium channel,was recently shown to control cancer cell migration,a critical step in metastasis outgrowth. Breast cancer becomes lethal when visceral metastases develop.Overexpression of the SK3 channel alters vascular Potier M,Joulin V,Roger S,Besson P,Jourdan ML,Leguennec JY,Bougnoux P,Vandier C.Identification of SK3 channel as a new mediator of breast cancer cell migration.Mol Cancer Ther 5 29462953,2006.

Overexpression of the SK3 channel alters vascular

Identification of SK3 channel as a new mediator of breast cancer cell migration.Mol Cancer Ther 5 29462953,2006.Crossref PubMed ISI Google Scholar; 23.Pringle KG ,Kind KL ,Sferruzzi-Perri AN ,Thompson JG ,Roberts CT.Beyond oxygen complex regulation andNovel Blocker of Onco SK3 Channels Derived from Scorpion SK3 channel was solely expressed in tumor breast biopsies and not in nontumor breast tissues.Thus,SK3 protein channel seems to be a new mediator of breast cancer cell migration and represents a Ion channels and transporters in tumour cell migration and Mar 19,2014 Identification of SK3 channel as a new mediator of breast#0183;2006 Identification of SK3 channel as a new mediator of breast cancer cell migration.Mol. 2004 Functional and molecular identification of intermediate-conductance Ca 2+ activated K + channels in breast cancer cells association with cell cycle progression.Am.J.Physiol.

Identification of SK3 channel as a new mediator of breast

Nov 01,2006 Identification of SK3 channel as a new mediator of breast#0183;Thus,SK3 protein channel seems to be a new mediator of breast cancer cell migration and represents a potential target for a new class of anticancer agents.[Mol Cancer Ther 2006;5(11):294653] Identification of SK3 channel as a new mediator of breast cancer cell migration Molecular Cancer TherapeuticsIdentification of KvLQT1 K+ channels as new regulators of Potier M,Joulin V,Roger S,Besson P,Jourdan ML,Leguennec JY,Bougnoux P and Vandier C Identification of SK3 channel as a new mediator of breast cancer cell migration.Mol Cancer Ther.5:29462953.2006.View Article Google Scholar PubMed/NCBI.32.Expression of KCNA5 Protein in Human Mammary Epithelial Apr 13,2016 Identification of SK3 channel as a new mediator of breast#0183;Potier M,Joulin V,Roger S,Besson P,Jourdan ML,Leguennec JY,Bougnoux P,Vandier C (2006) Identification of SK3 channel as a new mediator of breast cancer cell migration.Mol Cancer Ther 5:29462953

Expression and Contributions of TRPM7 and KCa2.3/SK3

Potier M,Joulin V,Roger S,Besson P,Jourdan ML,et al.(2006) Identification of SK3 channel as a new mediator of breast cancer cell migration.Mol Cancer Ther 5 29462953.[ PubMed ]Expression and Contributions of TRPM7 and KCa2.3/SK3 Potier M,Joulin V,Roger S,Besson P,Jourdan ML,et al.(2006) Identification of SK3 channel as a new mediator of breast cancer cell migration.Mol Cancer Ther 5 29462953.[ PubMed ]Effect of Quinoa Plant on Metastasis and Ion Channels of In this study,the effects of the quinoa plant on the rat brain cancer glioma cell line were examined.Rat C6 glioma cell lines were cultivated in Dulbecco's Minimum Essential Medium (DMEM) appendage with HAMS F 12 (1 1) and 2% FBS.

Effect of Quinoa Plant on Metastasis and Ion Channels of

In this study,the effects of the quinoa plant on the rat brain cancer glioma cell line were examined.Rat C6 glioma cell lines were cultivated in Dulbecco's Minimum Essential Medium (DMEM) appendage with HAMS F 12 (1 1) and 2% FBS.Cited by 57Publish Year 2011Author M.Potier,A.Chantome,V.Joulin,A.Girault,S.Roger,P.Besson,M.-L.Jourdan,J.-Y.Leguennec,Identification of SK3 channel as a new mediator of breast SK3 channel was solely expressed in tumor breast biopsies and not in nontumor breast tissues.Thus,SK3 protein channel seems to be a new mediator of breast cancer cell migration and represents a potential target for a new class of anticancer agents.[Mol Cancer Ther 2006;5(11):2946-53]Cited by 131Publish Year 2006Author Marie Potier,Virginie Joulin,S Identification of SK3 channel as a new mediator of breast#233;bastien Roger,Pierre Besson,Marie-Lise Jourdan,Jean-Yves LeGuennIdentification of SK3 channel as a new mediator of breast SK3 channel was solely expressed in tumor breast biopsies and not in nontumor breast tissues.Thus,SK3 protein channel seems to be a new mediator of breast cancer cell migration and represents a

Altered SK3/KCa2.3-mediated migration in adenomatous

SK3 channel was solely expressed in tumor breast biopsies and not in nontumor breast tissues.Thus,SK3 protein channel seems to be a new mediator of breast cancer cell migration and represents a Altered SK3/KCa2.3-mediated migration in adenomatous SK3 channel was solely expressed in tumor breast biopsies and not in nontumor breast tissues.Thus,SK3 protein channel seems to be a new mediator of breast cancer cell migration and represents a Altered SK3/KCa2.3-mediated migration in adenomatous Jun 18,2010 Identification of SK3 channel as a new mediator of breast#0183;Following Apc mutation SK3/KCa2.3 expression is largely reduced leading to a suppression of the SK3/KCa2.3 channel mediated-cell migration.Our findings reveal a previously unknown function of the SK3/KCa2.3 channel in epithelial colonic cells,and suggest that Apc is a powerful regulator SK3/KCa2.3 channel.

Altered SK3/KCa2.3-mediated migration in adenomatous

Jun 18,2010 Identification of SK3 channel as a new mediator of breast#0183;Following Apc mutation SK3/KCa2.3 expression is largely reduced leading to a suppression of the SK3/KCa2.3 channel mediated-cell migration.Our findings reveal a previously unknown function of the SK3/KCa2.3 channel in epithelial colonic cells,and suggest that Apc is a powerful regulator SK3/KCa2.3 channel.12345NextThe SK3/KCa2.3 potassium channel is a new cellular target Recently,we identified SK3/K Ca 2.3 channels as a new mediator of breast and melanoma cancer cell migration (Potier et al.,2006; Chantome et al.,2009).In the present study,we found that edelfosine reduced the migration of MDAMB435s cells by decreasing the activity of SK3/K Ca 2.3 channels and limiting Ca 2+ entry into cells.(PDF) The impact of down-regulated SK3 expressions on PDF Background Some Hirschsprungs disease (HSCR) patients showed persistent bowel symptoms following an appropriately performed pull-through Find,read and cite all the research you need

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